Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health

2018年,中国电影票房收入增长9%,达到89亿美元(约合609.8亿人民币)。
可口可乐(Coca-Cola)下调了今年的销售预测,该公司正艰难应对中国消费放缓,这导致该饮料集团股价下跌逾3%。
下面是2014年的几部重现活力、需要刮目相看的老剧——以及几部死气沉沉的老剧。
Although she has already reached astonishing levels of success for her age, Maddie only gives herself a nine out of ten in terms of her career achievements.
London Business School has topped the European table for the third year running — but continental rivals lead the European schools in the individual rankings used to compile it.
联系方式:Debbie McNally, Lakes Sotheby’s International Realty, (612) 388-1790; debbiemcnally.com
To SKN Company in Russia for exploding old Russian ammunition and creating diamonds. Now that`s recycling!
With best wishes for a happy New Year!
10. A bad marriage can lead to an early death
魔术队是所有队伍中最迷的哪一个。不论从纸面上看还是从球场表现来看,他们这样的队伍都毫无意义。
课程安排:5个住校学习时间段,不住校时在线学习
People promoting driverless cars, the most hyped industry segment of the moment, became world leaders in verbiage. Elon Musk claimed to be “laser-focused on achieving full self-driving capability on one integrated platform with an order of magnitude greater safety than the average manually driven car” (ie Tesla cars must stop crashing).
巴西政府动用数十亿资金建立新球场或扩建现有球场已触发众怒,并导致票价飞涨,这是路人皆知的事情。对此,一些球迷抱怨,曾经负担得起的现场体验变得更加昂贵,想要去诸如马拉卡纳等传奇球馆的热情也变淡了。
研究人员说,其中那7个砖石结构的坟墓可能是为富人建造的。
Single record of the year: "Over You," Miranda Lambert
['k?nsnis]
单词释义:
伦敦商学院的MBA课程位列欧洲第一,与美国哥伦比亚商学院(Columbia Business School)合办的EMBA课程位列第三,管理硕士课程首次参与排名就跻身前10名。参与管理硕士课程排名是伦敦商学院夺得欧洲榜首的关键因素。
He had been stranded for five hours by the time help arrived.
报名窗口将于周六关闭,报名成功者须参加11月29号的2016年国家公务员考试,考试通过后才可以参加明年3月的面试。
简而言之,C型人格的人是完美主义者, 始终如一,永远不会违反规则。 与A型人格的人不同的是,C型人会花时间处理细节,经常反复检查工作是否准确。他们往往是深思熟虑的人,喜欢了解自己工作和生活的每一个细节。
quality
11. Our gut bacteria are messing with us in ways we could never have imagined. New research has revealed that neurodegenerative diseases like Parkinson's might actually start out in the gut, rather than the brain, and there's mounting evidence that the human microbiome could be to blame for chronic fatigue syndrome. With gut bacteria showing signs of controlling our appetite, changing our brain structure, and triggering brain lesions that could lead to strokes, our tiny passengers are a force to be reckoned with.
According to the index, tourists are "spending overwhelmingly" to shop -- and not to dine -- in the top 20 destinations outside of Europe, despite many of them being world-famous cuisine capitals.
Harvard University topped the rankings for the 16th consecutive year, and Stanford University and University of Cambridge remained in second and third place, respectively.


By March, there's a real chance two or three of these prospects stick out as franchise players.
这将是一部非常有趣的电影,刻画出了美国队长与钢铁侠之间微妙的关系, 两人经常陷入信任危机。
Kobe Bryant really hasn't changed that much since high school, even though it's been 16 years since he's walked the halls of Lower Merion High School.


With the increasing proliferation and sophistication of mobile phones, wearable devices such as smart watches, and sensors that can measure and gather a variety of data, public interest is growing in using consumer electronics to take ownership of personal health and wellness. A 2015 survey found that 66% of Americans age 66 and older want to use mobile technologies to improve their health by receiving medication reminders and tracking diet and nutrition, physical activity, and symptoms.[1

3. 西北大学凯洛格商学院
最佳歌曲:
尽管增势坚挺,上个月年增长率还是从9月份的下跌0.8%,滑落至下跌1.4%。经济学家原本预计,在截至10月份的12个月里,日本工业产出下滑幅度为0.9%。
In Sex and the City, Miranda and Carrie frequent a place called Magnolia Bakery at 401 Bleeker Street. After the episodes aired, hordes of people had to investigate those cupcakes. Nothing can incur cupcake mania quite like Carrie Bradshaw can. Magnolia Bakery received a huge boost in sales and customers. In fact, they were so popular that they had to hire a "bouncer" of sorts. Not quite your typical club bouncer, this bouncer was friendly and very interested in the finer points of cupcakes.

Health apps and wearables
Health apps and wearables can unobtrusively gauge physiological and emotional states and collect, quantify, and monitor data regarding a user’s day-to-day behaviors. This “quantified self” can increase users’ self-awareness regarding their behavior and encourage positive changes to their overall health and well-being.[2] These commercially available devices also integrate an array of features to provide motivation through reward systems, opportunities for social in-teraction, tools for self-improvement, and prompts. The novelty, affordability, practicality, and ease of use have resulted in increased consumer enthusiasm and the pervasiveness of these devices.[3,4] With this growing interest in personal health, members of the general public are becoming more involved in monitoring and improving their own health habits.[5-10

Undoubtedly, merely tracking data through a device is not enough to maintain good health-related behaviors long-term, and the software must also incorporate motivational constructs important for the adoption and habituation of behaviors. For instance, a systematic review of studies that considered the use of electronic activity monitor systems found short-term changes in physical activity with self-monitoring, but no demonstration of superiority when the systems were compared with other interventions.[11] Another review of studies on the viability of using mobile technology for measuring and influencing physical activity found that most apps allow users to document their activity, set goals, review real-time feedback, connect to a social support network, and access online expertise.[12] However, less common among these apps were prompts to act and opportunities for problem solving and action planning, which are crucial constructs that translate intention into long-term behavior change.[13]

Sensor technologies
Sensor technologies have begun to enter the telehealth landscape and are primarily focused on continuous monitoring and precise diagnostics to inform management of various health conditions and diseases.[14-17] Sensors can be integrated into a watch or arm band or adhesive bandages and clothing, and then programmed to collect data on cardiac rhythm, heart rate, blood pressure, respiration, oxygen saturation, galvanic skin response, glucose levels, body temperature, body motions, ambient temperature, and global positioning. For health care providers, sensor inputs can permit remote monitoring, real-time teleconferencing, and timely care for patients with chronic diseases. For both patients and clinicians, telehealth supported by sensors can have profound implications. Clinicians can provide timely and patient-centred care to those living at a distance with chronic disease and can coordinate care when multiple providers are involved, reducing costs to the health care system.

A current clinical example is the management of paroxysmal atrial fibrillation with a mobile ECG and app that monitors the patient’s electrical rhythm to detect frequency and patterns of arrhythmias, and may even allow patients to share ultrasound and electrocardiogram data with their health care provider.[18-20] Telemonitoring with sensors can also support self-management of chronic diseases and detect early signs of deterioration in health requiring immediate treatment and advice.[21] Studies to date have demonstrated some clinical promise for the use of home telemonitoring in the context of heart failure and diabetes. A recent Cochrane review found that telemonitoring was an effective way to lower levels of glycated hemoglobin and low-density lipoprotein.[22] Although several studies on heart failure have produced conflicting results regarding the overall benefits of home monitoring,[23-26] systematic reviews have suggested that home telemonitoring reduces all-cause mortality and hospitalizations, and improves quality of life compared with usual care.[22,27] In addition, features such as automated and mobile telemonitoring appear to be more effective compared with other forms of home telemonitoring.[27]

Further studies are needed to determine how home health monitoring can improve patient safety during the transition from acute care to community care, and to examine the impact of home monitoring on health care costs. TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), an initiative of the University of British Columbia and Vancouver Coastal Health, is seeking to do this with prospective trials designed to uncover how telemonitoring can support the safety of heart failure patients discharged from hospital to home.[28]

Mobile apps, wearables, and sensors in the clinical setting
Even though mobile apps, wearables, and sensor technologies are promising, further research is needed to validate their use and long-term impact.[29] This research will require the collaboration of clinicians, health researchers, engineers, and computer scientists.[30] Understanding the possible risks of using these technologies, from physiological harm to breaching of privacy and confidentiality with insecure devices, and how to mitigate any risks is also important. Other important issues to consider include patient anxiety with overuse of technologies, health data piracy, self-diagnosis resulting from overreliance on self-monitoring, and patients not seeking help appropriately. These technologies should be used only as complementary tools in the treatment and prevention of health conditions and disease and should not be used in isolation by patients who self-diagnose and self-manage without consulting a health professional. 

With the prices of most commodities having recovered somewhat since February 2016, the year-on-year fall in unit prices has slowed to around 5 per cent.

Instant Heart Rate by Azumio.[31] A free app downloadable to both Apple and Android operating systems that measures heart rate and displays a monitoring strip. As well as helping users accurately track their heart rates, the app is capable of detecting irregular rhythms when palpitations occur. 

Sleep Time by Azumio.[32] A free app that monitors sleep patterns, sleep efficiency, and also acts as an alarm clock. Users can know how often they go into light and deep sleep, and recognize how much of these types of sleep will be necessary for them to feel rested, thereby quantifying the amount of true sleep they need and not just how long they should stay in bed. 

Bellybio Interactive Breating by RelaxLine.[33] A free app that helps users pace their breathing to achieve calmness. Placing the mobile phone against the abdomen, users can follow the sounds emitted to practise deep, abdominal breathing using this simple yet surprisingly effective tool. 

? Aid workers are worried about a food crisis in Haiti, where Hurricane Sandy killed 52 people last week. The UN is also concerned that flooding could lead to a sharp rise in cholera cases. At least 69 people were killed by Sandy in the Caribbean.
Libby has posted the lyrics on her YouTube channel in the comments section, but here they are for you. There are plenty of lovely English expressions and British English slang that I’ve highlighted in bold for you. Can you guess the meaning? What does “OMG” stand for?

排名部分基于校友们在职场上的成功程度,衡量标准为薪资数据。
charity
Blake Griffin's high school appearance isn't that far off from how he looks today. Just add some hair and some size to his biceps, and you've got Blake Griffin today.
报告指出,缺少资金和经验是大学生创业者们面临的最大障碍,40%的年轻创业者们依赖于诸如来自银行、投资机构、学校和政府等机构贷款的外部资金。
'It surprised me, but it's a good sign for Tencent getting abroad, because in particular WeChat is a combination of WhatsApp and Instagram, so it's a unique value proposition that is probably pretty good for emerging market consumers,' he said.
据该报告显示,苹果的品牌价值同比去年增长了5%,至1780亿美元,而谷歌的品牌价值同比增长了11%,至1330亿美元。

Discernment to determine whether a particular app, wearable, or sensor can be effective.
Expertise and experience to guide patients on the use of technology.
Partnership with patients in pursuit of optimal health through technology use.
Trials to closely monitor benefits and drawbacks.
Humility to recognize that patients may know and invest much more time than physicians in looking for these tools.34

Conclusions
Based on today’s rapid pace of development and public enthusiasm for the technology marketplace, health apps, wearables, and sensors will soon become integral to our patients’ pursuits of good health and will need to be integrated in clinical practice. Physicians must be active agents in these evolutionary times, guiding patients, advocating for evidence to support the use of technologies, and participating in the development and incorporation of technology in patient wellness journeys. Through clinical stewardship and partnership with patients, physicians can use their expertise and experience to guide the growth of innovations into mainstream health care.

Competing interests
Dr Ho receives no personal financial compensation as the principal investigator of TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), a project funded by a Canadian Institutes of Health Research grant. This grant is matched by the Michael Smith Foundation for Health Research and the BC Ministry of Health, with additional support provided by TELUS Health and Sentrian. TELUS Health, Cisco, and Avizia have also provided equipment for display in Dr Ho’s Demonstration and Simulation Studio for Health (DaSSH) at UBC. Mr Yao and Dr Lauscher have no competing interests to declare.


缓解楼市虚火过旺 通州连夜限购不足为怪


References

1. Cision PR Newswire. Fifth annual Pulse of Online Health survey finds 66% of Americans eager to leverage digital tools to manage personal health. Posted 24 February 2015. Accessed 28 August 2017. www.prnewswire.com/news-releases/fifth-annual-pulse-of-online-health-survey-finds-66-of-americans-eager-to-leverage-digital-tools-to-manage-personal-health-300039986.html.

2. Swan M. Emerging patient-driven health care models: An examination of health social networks, consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009;6:492-525.

3. Gao Y, Li H, Luo Y. An empirical study of wearable technology acceptance in healthcare. Ind Manag Data Syst 2010;115:1704-1723.

4. Kim KJ, Shin DH. An acceptance model for smart watches: Implications for the adoption of future wearable technology. Internet Res 2015;25:527-541.

5. West JH, Hall PC, Hanson CL, et al. There’s an app for that: Content analysis of paid health and fitness apps. J Med Internet Res 2012;14:e72.

6. Abroms LC, Padmanabhan N, Thaweethai L, Phillips T. iPhone apps for smoking cessation: A content analysis. Am J Prev Med 2011;40:279-285.

7. Cowan LT, Van Wagenen SA, Brown BA, et al. Apps of steel: Are exercise apps providing consumers with realistic expectations? A content analysis of exercise apps for presence of behavior change theory. Health Educ Behav 2013;40:133-139.

8. Azar KM, Lesser LI, Laing BY, et al. Mobile applications for weight management. Am J Prev Med 2013;45:583-589.

9. Breland JY, Yeh VM, Yu J. Adherence to evidence-based guidelines among diabetes self-management apps. Transl Behav Med 2013;3:277-286.

10. Lyons EJ, Lewis ZH, Mayrsohn BG, Rowland JL. Behavior change techniques implemented in electronic lifestyle activity monitors: A systematic content analysis. J Med Internet Res 2014;16:e192.

11. Lewis ZH, Lyons EJ, Jarvis JM, Baillargeon J. Using an electronic activity monitor system as an intervention modality: A systematic review. BMC Public Health 2015;15:585.

12. Bort-Roig J, Gilson ND, Puig-Ribera A, et al. Measuring and influencing physical activity with smartphone technology: A systematic review. Sports Med 2014;44:671-686.

13. Rhodes RE, Yao CA. Models accounting for intention-behavior discordance in the physical activity domain: A user’s guide, content overview, and review of current evidence. Int J Behav Nutr Phys Act 2015;12:1-14.

14. Chen M, Gonzalez S, Vasilakos A, et al. Body area networks: A survey. Mob Networks Appl 2011;16:171-193.

15. Appelboom G, Camacho E, Abraham ME, et al. Smart wearable body sensors for patient self-assessment and monitoring. Arch Public Health 2014;72:28.

16. Chan M, Estève D, Fourniols JY, et al. Smart wearable systems: Current status and future challenges. Artif Intell Med 2012;56:137-156.

17. Alemdar H, Ersoy C. Wireless sensor networks for healthcare: A survey. Comput Networks 2010;54:2688-2710.

18. Haberman ZC, Jahn RT, Bose R, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J Cardiovasc Electrophysiol 2015;26:520-526.

19. Ferdman DJ, Liberman L, Silver ES. A smartphone application to diagnose the mechanism of pediatric supraventricular tachycardia. Pediatr Cardiol 2015;36:1452-1457.

20. Baquero GA, Banchs JE, Ahmed S, et al. Surface 12 lead electrocardiogram recordings using smart phone technology. J Electrocardiol 2015;48:1-7.

21. Wootton R. Twenty years of telemedicine in chronic disease management—An evidence synthesis. J Telemed Telecare 2012;18:211-220.

22. Flodgren G, Rachas A, Farmer A, et al. Interactive telemedicine: Effects on professional practice and health care outcomes. Cochrane Database System Rev 2015;(9):CD002098.

23. Mortara A, Pinna GD, Johnson P, et al. Home telemonitoring in heart failure patients: The HHH study (Home or Hospital in Heart Failure). Eur J Heart Fail 2009;11:312-318.

24. Dar O, Riley J, Chapman C, et al. A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: Results of the Home-HF study. Eur J Heart Fail 2009;11:319-325.

25. Chaudhry SI, Mattera JA, Curtis JP, et al. Telemonitoring in patients with heart failure. N Engl J Med 2010;363:2301-2309.

26. Koehler F, Winkler S, Schieber M, et al. Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: The Telemedical Interventional Monitoring in Heart Failure study. Circulation 2011;123:1873-1880.

27. Kitsiou S, Pare G, Jaana M. Effects of home telemonitoring interventions on patients with chronic heart failure: An overview of systematic reviews. J Med Internet Res 2015;17:e63.

28. TEC4Home Healthcare Innovation Community. Supporting heart failure patient transitions from acute to community care with home telemonitoring technology: A protocol for a provincial randomized controlled trial (TEC4Home). JMIR Res Protoc 2016;5:e198. 

29. Yao C, Ho K. Mobile sensors and wearable technologies. In: Amelung VE, Stein V, Goodwin N, et al., editors. Handbook integrated care. Cham, Switzerland: Springer; 2017.

30. Ho K, Borycki E, Kushniruk A, et al. The health perspective in using digital media for health and wellness. Presented at the IEEE International Digital Media Industry Forum, Boston, MA, 4-6 July 2016.

31. Azumio Inc. Instant heart rate. Accessed 28 August 2017. www.azumio.com/s/instantheartrate/index.html. 

32. Azumio Inc. Sleep time. Accessed 28 August 2017. www.azumio.com/s/sleeptime/index.html. 

33. RelaxLine. BellyBio. Accessed 28 August 2017. https://itunes.apple.com/ca/app/bellybio-interactive-breathing/id353763955?mt=8.

34. Ho K. How health information technologies are enhancing health of patients and their doctors. Presentation at the Alberta Medical Association 2015 Spring Representatives Forum, Edmonton, AB, 13 March 2015.


数据还显示,网红的分布和经济发展水平也有密切关系,北京、上海、广东、江苏和浙江等较发达地区是网红分布最多的五个地区。
《橘色》,导演:肖恩·贝克(Sean Baker)。
智联招聘高级职业顾问王一新表示:“虽然国家政策、各大高校和投资环境给大学生创业提供了良好的土壤,但鉴于大学生经验欠缺、资源积累不足、人脉不足等原因,目前大学生创业成功的概率并不高。”
或许,在纽约尼克斯夺取NBA总冠军的道路上,缺失的关键就是甜瓜(安东尼的昵称)。噢,不,等等,林书豪才是他们欠缺的一环。然而,无论怎样,甜瓜不会妨碍尼克斯的冠军梦。
Recipient: Canadian Prime Minister Justin Trudeau
但是白人身份认同的斗争不仅仅是个政治问题,它也是一个“深藏的”故事,一个看到别人都在向前,自己却感觉困在原地的故事。
我们发展出人工记录声音的技术已经有几十年了,但是人工植入器官在耳朵这一领域没有任何改变。你可能认为生长在头两边的肉块极易替换,因为它们只是皮和软骨,而不是复杂的器官。事实上,科学家在制作假耳上并没有做得非常出色。传统的替代耳朵看起来或感觉起来都像塑料玩具。
如果一并考虑过去几天里公布的数据,情况也不会变得更好。上个月,日本仍在与通缩和家庭开支下滑作斗争。不过,今天早上公布的零售业销售数据超出了人们的估计。
如果观众还不知道这部影片是以20世纪80年代初为背景,那看一眼安娜的直刘海就知道了。她留着齐肩长发,刘海以外的部分在脸庞四周形成微微弯曲的弧度。这个造型很简单,但对这个女人来说显得很有力量,她丈夫艾贝尔(奥斯卡·伊萨克[Oscar Isaac]饰)经营取暖油生意,不过她的过去更为复杂。
Mr Ravenscroft ended up leaving teaching to found Enabling Enterprise, a body that seeks to bridge the gulf between schools and business by taking pupils out of the classroom and giving them practical projects and visits to businesses, including UBS, the bank, and Freshfields, the law firm.

Kendall Ho, MD, FRCPC, Christopher Yao, MSc, Helen Novak Lauscher, PhD. Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health. BCMJ, Vol. 59, No. 10, December, 2017, Page(s) 503-506 - Clinical Articles.



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伦敦——在20世纪70年代,英国喜剧演员汤米·库珀(Tommy Cooper)讲过这样一个笑话:他在阁楼里发现一把小提琴和一幅画,让拍卖公司估价。拍卖公司说,好消息是它们分别出自斯特拉迪瓦里(Stradivarius)和伦勃朗(Rembrandt)之手。坏消息是那幅画是斯特拉迪瓦里画的,小提琴是伦勃朗做的。
愿新年不仅是你欢笑的时刻,更是你欣喜的日子。祝福你。
尽管人工智能取得了突破,阿里巴巴集团董事局主席马云却认为,人类不需要惧怕机器。
“The Big Short” (Adam McKay)

Apple Inc.'s Chief Executive Officer Steve Jobs is shown in this combination photo of file photographs dating (top row L to R) July 2000, November 2003, September 2005, (bottom L to R) September 2006, January 2007 and September 2008. Jobs will take a medical leave of absence until the end of June because his health problems are "more complex" than he had thought, shocking investors and sending the company's shares down as much as 10 percent on January 14, 2009.

  • Only the first three authors are listed, followed by "et al."
  • 绿色智能制造成行业下一个风口
  • 斩断“大棚房”背后的利益链


菲律宾警察总长表示,新总统罗德里戈?杜特尔特(Rodrigo Duterte)上台后,不断升级的禁毒战争已造成近1800人死亡。
The pair came out with a spree of punch lines, dishing them around the Beverly Hills Hilton, much to the delight of its starry audience. Mr. Damon, Meryl Streep and, naturally, Mr. Clooney were among the targets. Ms. Fey particularly had the crowd roaring with a description of 'Gravity,' which stars Sandra Bullock and Mr. Clooney.

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